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Computer software for development and simulation of compartmental models of neurons.

E. De Schutter

Computers in Biology and Medicine 19:71-81 (1989)

Abstract - A software package `Nodus for simulation and development of compartmental models of neurons is described. Passive or excitable membrane with voltage dependent ion conductances or synaptic conductances can be modeled. Detailed simulations of morphology and electrophysiology of neurons are possible. Neurophysiological experiments like voltage clamps and complex current injections can be simulated. Two integration methods are available: a fast hybrid method and an accurate fifth order Runge-Kutta method, with variable time steps. Nodus is implemented on Apple Macintosh microcomputers, with the standard user interface and interactive graphics. Simulations of simple test models demonstrate the accuracy and computation speed of the application.