Skip navigation


Dendritic calcium channels amplify the variability of postsynaptic responses.

E. De Schutter


CSCC Annual Report 1994-1995 1994-1995:- (1995)

Abstract - Over the last years it has become increasingly clear that many neurons possess dendritic calcium channels. The cerebellar Purkinje cell is the classic example (LlinĂ¡s and Sugimori 1980), but pyramidal cells in the cortex (Amitai et al. 1993) and in the hippocampus (Jaffe et al. 1994) also have high densities of calcium channels in their dendrite. The role of such channels in dendritic processing is not entirely clear. Spencer and Kandel (1961) first proposed that voltage-dependent dendritic channels could amplify large synaptic inputs, presumably resulting in a larger somatic response. Recently, Markram and Sakmann (1994) demonstrated in cortical pyramidal cells that single (subthreshold) EPSPs can cause activation of dendritic calcium channels. Similar results where reported for Purkinje cells (Eilers et al. 1995).