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Anatomical structure alone can not predict function.

D. Jaeger, E. De Schutter

Behavioral and Brain Sciences 20:252 (1997)

Abstract - The central hypothesis of the target article that tidal waves of parallel fiber excitation precisely activate Purkinje cell spiking is hard to reconcile with recent neurophysiological and modeling data. The assumed pattern of mossy fiber input seems unrealistic, inhibition is likely to interfere with the proposed excitatory responses, and moreover, computer simulations show that the Purkinjecell is a poor coincidence detector.