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Detailed model of ryanodine receptor-mediated calcium release in Purkinje cells.

E. De Schutter


Computational Neuroscience: Trends in research 1998:161-166 (1998)

Abstract - Ryanodine receptor-mediated calcium release was modeled in a compartmental model of the Purkinje cell with a detailed representation of buffered calcium diffusion. For several important parameters no constraining experimental data were available. The importance of the threshold of activation of release and of the unbinding rate of the main calcium buffer in the stores (calsequestrin) is described. Using reasonable assumptions for these parameters, calcium influx during voltage-gated calcium spikes can activate ryanodine receptors in the submembrane region without noticeably changing the firing pattern of the model.