[Comp-neuro] Free Online Seminar: How to build your own Connectome?
markus.butz-ostendorf at biomax.com
Fri Nov 6 17:23:32 CET 2020
My apologies for cross-postings first of all!
I would like to draw your attention to our second online seminar on
Connectomics. We have invited our clinical neuroimaging specialist Dr
Yong Li from Biomax Brain Science to demonstrate how brain tumors change
the human Connectome and how the Connectome heals after tumor surgery.
Abstract at the end of this message. The seminar takes place online on
Tue, 10 Nov 2020 at 3pm (CET). Participation is free of charge but
registration is kindly requested via this link
Explore NICARA yourself by registering a free demo account at
Brain damage such as tumors, traumatic brain injury or stroke alter the
characteristics of the broader connectome—the map of all neural
connections in the brain. A hot topic in ongoing research using the
connectome approach is how brain rewiring can compensate for
lesion-induced cognitive deficits before and after intervention. The
site of a lesion within the connectome is critical. Damage of a node
that acts e.g. as an integrator hub of several subnetworks is
significantly more detrimental to cognitive functions than a damaged
node with low connectivity or existing by-passes. Understanding brain
rewiring in response to lesions is the major focus of clinical as well
as computational neuroscience projects (such as The Virtual Brain) to
pave the way for personalized medicine in neurology and related fields.
In this online seminar we will focus on brain tumors and explore their
effects on the connectome using NICARA™. A particular image processing
pipeline in NICARA, employing the best available open-source tools for
image preprocessing and probabilistic fiber tracking, enabled us to
automatically extract full brain tractography based structural
connectome data from DTI raw images. Besides the pipeline, we will
discuss quality control mechanisms especially designed for the
assessment of large cohorts. As an example, data set we used the Brain
Tumor Connectomics Data (Aerts H et al. Modeling Brain Dynamics in Brain
Tumor Patients Using the Virtual Brain. eNeuro. 2018 Jun 4;5(3):
ENEURO.0083-18.2018.) and assessed alterations in major white matter
fiber tracts before and after surgery. For quantification, provided not
only the abstract presentation of digitalized connectome networks in MNI
space by a 3D lattice graphs but also offered fiber density maps
directly in the patient’s native T1w for a precise judgement of fiber
pathway density distribution in the vicinity of, and remote to, a tumor.
Our clinical neuroimaging specialist Dr. Yong Li will further show how
he uses NICARA to explore, manage and compare extracted connectome
networks for group comparisons, individual patient-matched controls
comparisons and longitudinal assessments. NICARA is a novel neuroimaging
tool created by clinical neuroimaging scientists for clinical and
translational neuroscience users. A technical introduction by product
manager Dr. Markus Butz-Ostendorf at the end of the seminar on how
NICARA stores and retrieves connectome information using of knowledge
models will complement the scientific presentation.
The seminar will take place on November 10, 2020 at 3:00 p.m. (CET) and
will last about 45 minutes. Make use of this opportunity and register
today at www.biomax.com/webinar.
Next seminar for Pharmacologists :
1/12/2020, 3:00 pm
To register, please go to https://www.biomax.com/webinar and request
your access data via the webinar page.
We are looking forward to meeting you.
Dr. rer. nat. Markus Butz-Ostendorf
Innovation Manager Brain Science
Senior Product Manager
Biomax Informatics AG
Robert-Koch-Str. 2, 82152 Planegg, Germany
Registergericht: Amtsgericht München, HRB 134442
Vorstand: Dr. Klaus Heumann
Vorsitzender des Aufsichtsrates: Prof. Dr. Hans-Werner Mewes
Tel: +49 89 895574-862
Fax: +49 89 895574-825
Email:markus.butz-ostendorf at biomax.com
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