[Comp-neuro] Fully funded PhD in Electrophysiology: Closed-loop Transcranial Electric Stimulation
axel.hutt at inria.fr
Thu Jun 18 08:27:30 CEST 2020
PhD-project in electrophysiology:
Closed-loop Transcranial Electric Stimulation of Neural Networks
in a Rodent Model of Psychosis Transition.
Patients suffering from schizophrenia develop resistance to chemical
treatments. Transcranial electrical stimulation (TES), a non-invasive
neurophysiological approach, has been shown to alleviate some symptoms,
to improve cognitive performances, and to modulate the corticothalamic
connectivity. The goal of the project is to optimize a combination of
stimulation parameters that make it efficient for the TES against the
psychosis transition using predictive electrical biomarkers. In healthy
humans and rodents, ketamine reproduces, with a single psychotomimetic
dose, the abnormal amplification of corticothalamic gamma-frequency
(30-80 Hz) oscillations recorded in individuals having a high-risk mental
state for a psychosis transition. Gamma oscillations are naturally
involved in cognition, which is also disrupted in at-risk patients. It
was demonstrated that the ketamine-induced gamma hyperactivity is prevented
by the antipsychotic clozapine.
The Ph.D. student will experimentally investigate the TES in the ketamine
rodent model of psychosis transition. In an attempt to optimize a
combination of stimulation parameters with potential preventive/curative
effects, the Ph.D. student will develop and build up a closed-loop feedback
system that controls the TES optimally using a Kalman filter.
The ideal candidate will have a strong background in neuroscience,
preferably with experience in in-vivo electrophysiological techniques,
mathematical and statistical skills for data analysis (EEG and cellular),
and basic knowledge in numerical programming and neural modelling.
Start of the position will be Fall 2020, with duration of 36 months.
Funding source: INRIA (Action Exploratoire A/D Drugs).
Axel Hutt, Inria – MIMESIS
Email: axel.hutt at inria.fr
team web page: https://mimesis.inria.fr/
Didier Pinault, Inserm – U1114
Email: pinault at unistra.fr
lab web page: https://www.u1114.inserm.fr/
Please send your application documents (CV and 1 recommendation letter)
by email to Axel Hutt.
More information about the Comp-neuro