Hugo-Geerts at In-Silico-Biosciences.com Hugo-Geerts at In-Silico-Biosciences.com
Sun Nov 3 13:50:49 CET 2019

Do you want to make a difference in the life of patients suffering from
chronic pain? Are you motivated to help solving the opioid epidemic? 

In Silico Biosciences (www.in-silico-biosciences.com), a pioneer in
Quantitative Systems Pharmacology (QSP) for R&D in CNS diseases has openings
for computational neuroscientists. The fully funded European Pain project
(duration 3.5 years with start in early 2020) aims to develop an actionable
biophysically realistic computer model of the relevant human neuronal
circuits for analgesia, sedation, cognitive impairment, and substance abuse
liability for opioids. These models will be integrated in an existing QSP
platform for the introduction of approved therapeutic medications based on
their pharmacological properties for combination therapy. 

The models will be developed based on preclinical knowledge combined with
human neurophysiology and imaging studies of relevant neuronal circuits,
will be calibrated using biomarkers and therapeutic interventions in human
patients and predictions will be tested in preclinical models and in
clinical studies.  

This is an unique opportunity to work in a world-class multi-disciplinary
consortium ranging from preclinical studies over computer modeling of
pharmacological interventions to clinical studies and at the same time
pursuing a meaningful outcome for patients.

The platform is based on NEURON software. The positions are at both post-doc
and graduate student level, with the opportunity to pursue a PhD and can be
embedded in the Leiden-Amsterdam Center for Drug Research in Leiden, the
Netherlands.  However, alternative locations and flexible remote working
arrangements can be considered depending on individual circumstances. Salary
is commensurate with experience. 

Please send your CV, covering letter and the names of two references to
Hugo-Geerts at In-Silico-Biosciences.com


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