[Comp-neuro] Fully funded PhD position in neuroscience about cone photoreceptor signal transduction at Ecole Normale Superieure in Paris

Juergen Reingruber reingrub at ens.fr
Wed Jul 31 11:01:48 CEST 2019

Please forward this offer among potentially interested students. Thanks. 
Jürgen Reingruber

Development of a Mathematical Model of Signal Transduction and 
Adaptation in Mammalian Cone Photoreceptors

Field: Computational Neuroscience, Sensory Transduction
Location: Institute of Biology École Normale Supérieure, Paris
Supervision: Jürgen Reingruber, IBENS
Collaboration: G. Fain and A. P. Sampath from UCLA
Funding: 42 months by ANR, starting earliest in October 2019

Project description: We are looking for a PhD student for an 
interdisciplinary project between physics, mathematics computer science 
and neuroscience. Cone photoreceptors are the fundamental retinal 
neurons underlying our daylight vision. In spite of their importance for 
our visual perception, a comprehensive biophysical model showing how 
cones convert light into an electrical signal has not yet been 
developed. In close partnership with our experimental collaborators from 
UCLA, the student will analyze new (and worldwide unique) 
electrophysiological recordings to develop the first molecular model for 
the light response in cones. He will use asymptotic analysis and 
simulations to obtain a precise understanding of how cones respond and 
adapt during daylight. He will perform simulations with molecularly 
modified models to study how sensory transduction is altered in a 
diseased photoreceptor, which is important for understanding and 
treatment of photoreceptor dysfunctions. More details about the project 
can be found here:

Lab and Environment: The lab where the research will be conducted is 
located in the Institute of Biology at École Normale Supérieure in the 
Latin Quarter in Paris. The ENS is a leading multidisciplinary research 
center and part of the PSL university. It is located in the heart of 
Paris right next Collège de France, Institute Curie, EPSCI (school of 
engineering), Sorbonne and other universities. The lab provides high 
speed internet, a powerful workstation (iMac) and access to Bioclust, 
the IBENS computing cluster. The lab comprises PhD students and postdocs 
with background in physics, applied mathematics and computer science.

Candidate: The candidate should have a solid background in physics, 
applied mathematics, computer science or equivalent. Her/he should be 
highly motivated and interested in neuroscience and biology. Ideally the 
candidate should have skills and experience in modeling, analysis of 
dynamical systems, stochastic processes as well as programming and 
running simulations using either Matlab, C/C++, Comsol or Python.

To apply, please send a CV and a motivation letter to Jürgen Reingruber 
(reingrub at ens.fr).

Jürgen Reingruber, PhD
Institute of Biology (IBENS)
École Normale Supérieure
46 rue d'Ulm, 75005 Paris, France
Tel: +33 (0)1 4432 3662
Fax: +33 (0)1 4432 8887

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