[Comp-neuro] A databank for intracellular electrophysiological recordings of adult somatosensory cortex

Fleur Zeldenrust f.zeldenrust at neurophysiology.nl
Mon Dec 24 11:16:46 CET 2018


Dear all,

It is our pleasure to share with you a large database of whole-cell
intracellular recordings from 315 neurons located in the supragranular
layers (L2/3) of the primary somatosensory cortex in adult mice (9-45 weeks
old) from both sexes (females, N=195; males, N=120). Data include 361
somatic current-clamp (CC) and 476 voltage-clamp (VC) experiments, recorded
using a step-and-hold protocol (CC, N=257; VC, N=46), frozen noise
injections (CC, N=104) and triangular voltage sweeps (VC, 10 (N=132), 50
(N=146) and 100 ms (N=152)), from regular spiking (N=169) and fast-spiking
neurons (N=66).

We believe that this database will particularly benefit computational
modellers, as the data can be used to systematically study the properties
of somatic integration, and the principles of action potential generation
across sexes and across electrically characterised neuronal classes in
adulthood. Understanding the principles of the somatic transformation of
postsynaptic potentials into action potentials will shed light onto the
computational principles of intracellular information transfer in single
neurons and information processing in neuronal networks, helping to
recreate neuronal functions in artificial systems.

So feel free to use the data for your (cortical) cell models!

The data can be found here: http://gigadb.org/dataset/100535
The paper can be found here:  https://doi.org/10.1093/gigascience/giy147

Best regards and happy holidays,

Angelica da Silva Lantyer
Niccolò Calcini
Ate Bijlsma
Koen Kole
Melanie Emmelkamp
Manon Peeters
Wim J. J. Scheenen
Fleur Zeldenrust
Tansu Celikel

-- 
Fleur Zeldenrust
Assistant Professor
Department of Neurophysiology
Donders Institute for Brain, Cognition and Behaviour
Faculty of Science, Radboud University
Heyendaalseweg 135, postvak 33, kamer 02.204
6525 AJ Nijmegen, the Netherlands
tel +31 24 36 53195
fleurzeldenrust.nl
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