[Comp-neuro] New Book: The Rewiring Brain

Arjen van Ooyen arjen.van.ooyen at gmail.com
Thu Jul 6 10:05:52 CEST 2017

Dear colleagues,

​We would like to draw your attention to our recently published book:
*The Rewiring Brain: A Computational Approach to Structural Plasticity in
the Adult Brain*, van Ooyen, A, and Butz-Ostendorf, M, eds, Academic Press,
June 2017.

For more information (preview) and to order the book, go to

Also see https://anvooyen.home.xs4all.nl/papers/TheRewiringBrain.html


The adult brain is not as hard-wired as traditionally thought. By modifying
their small- or large-scale morphology, neurons can make new synaptic
connections or break existing ones (structural plasticity). Structural
changes accompany memory formation and learning, and are induced by
neurogenesis, neurodegeneration and brain injury such as stroke.

Exploring the role of structural plasticity in the brain can be greatly
assisted by mathematical and computational models, as they enable us to
bridge the gap between system-level dynamics and lower level cellular and
molecular processes. However, most traditional neural network models have
fixed neuronal morphologies and a static connectivity pattern, with
plasticity merely arising from changes in the strength of existing synapses
(synaptic plasticity). In *The Rewiring Brain*, the editors bring together,
for the first time, contemporary modeling studies that investigate the
implications of structural plasticity for brain function and pathology.
Starting with an experimental background on structural plasticity in the
adult brain, the book covers computational studies on homeostatic
structural plasticity, the impact of structural plasticity on cognition and
cortical connectivity, the interaction between synaptic and structural
plasticity, neurogenesis-related structural plasticity, and structural
plasticity in neurological disorders.

Structural plasticity adds a whole new dimension to brain plasticity, and *The
Rewiring Brain* shows how computational approaches may help to gain a
better understanding of the full adaptive potential of the adult brain. The
book is written for both computational and experimental neuroscientists.

Key features:

·      Reviews the current state of knowledge of structural plasticity in
the adult brain.

·      Gives a comprehensive overview of computational studies on
structural plasticity

·      Provides insights into the potential driving forces of structural
plasticity and the functional implications of structural plasticity for
learning and memory

·      Serves as inspiration for developing novel treatment strategies for
stimulating functional repair after brain damage

*Book Contents*


*Arjen van Ooyen and Markus Butz-Ostendorf*

Section I. Experimental background

1. Structural plasticity and cortical connectivity
*Vassilis Kehayas and Anthony Holtmaat*
2. Structural plasticity induced by adult neurogenesis
*Gregory W. Kirschen, Kurt A. Sailor, and Shaoyu Ge*
3.  Structural neural plasticity during stroke recovery
*Kimberly Gerrow and Craig E. Brown*
4. Is lesion-induced synaptic rewiring driven by activity homeostasis?
*Markus Butz-Ostendorf and Arjen van Ooyen*

Section II. Homeostatic structural plasticity

5. Network formation through activity-dependent neurite outgrowth: a review
of a simple model of homeostatic structural plasticity
*Arjen van Ooyen*
6. Clustered arrangement of inhibitory neurons can lead to oscillatory
dynamics in a model of activity-dependent structural plasticity
*Rosanna C. Barnard, Istvan Z. Kiss, Simon F. Farmer, and Luc Berthouze*
7. A detailed model of homeostatic structural plasticity based on dendritic
spine and axonal bouton dynamic
*s**Markus Butz-Ostendorf and Arjen van Ooyen*
8. Critical periods emerge from homeostatic structural plasticity in a
full-scale model of the developing cortical column
*Sebastian Rinke, Mikael Naveau, Felix Wolf and Markus Butz-Ostendorf*
9. Lesion-induced dendritic remodeling as a new mechanism of homeostatic
structural plasticity in the adult brain
*Steffen Platschek, Hermann Cuntz, Thomas Deller, and Peter Jedlicka*

Section III. Structural plasticity and connectivity

10. The role of structural plasticity in producing nonrandom neural
*Paul Miller*
11. Structural plasticity and the generation of bidirectional connectivity
*Daniel Miner, Felix Z. Hoffmann, Florence Kleberg, and Jochen Triesch*
12. Spike timing-dependent structural plasticity of multicontact synaptic
*Moritz Deger*
13. Selection of synaptic connections by wiring plasticity for robust
learning by synaptic weight plasticity
*Naoki Hiratani and Tomoki Fukai*

Section IV. Structural plasticity and learning and memory

14. Within a spine's reach
*Will DeBello and Karen Zito*
15. Impact of structural plasticity on memory capacity
*Panagiotis Bozelos and Panayiota Poirazi*
16. Long-term information storage by the interaction of synaptic and
structural plasticity
*Michael Fauth, Florentin Wörgötter, and Christian Tetzlaff*
17. Impact of structural plasticity on memory formation and decline
*Andreas Knoblauch*

Section V. Neurogenesis-related structural plasticity

18. Adult neurogenesis and synaptic rewiring in the hippocampal dentate
*Arjen van Ooyen, Gertraud Teuchert-Noodt, Keren Grafen, and Markus
19. Modifications in network structure and excitability may drive
differential activity dependent integration of granule cells into dentate
gyrus circuits during normal and pathological adult neurogenesis
*Quinton Skilling, James Roach, Alison L. Althaus, Geoffrey G. Murphy,
Leonard Sander, and Michal Zochowski*
20. Computational perspectives on adult neurogenesis
*Kristofor D. Carlson, Fredrick Rothganger, and James B. Aimone*
21. Restricted boltzmann machine models of hippocampal coding and
*Rory Finnegan, Mark Shaw, and Suzanna Becker*

Section VI. Structural plasticity and pathology

22. Modeling the impact of lesions in the brain
*Sol Lim, Frances Hutchings, and Marcus Kaiser*
23. Network models of epilepsy-related pathological structural and
functional alterations in the dentate gyrus
*Ivan Raikov, Mark Plitt, and Ivan Soltesz*
24. Computational models of stroke recovery
*Vittorio Sanguineti*
25. Neural plasticity in human brain connectivity: the effects of deep
brain stimulation
*Tim J. van Hartevelt, Henrique M. Fernandes, Angus B. A. Stevner, Gustavo
Deco, and Morten L. Kringelbach*
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