[Comp-neuro] PhD positions in Marie-Curie European Training Network (Synaptic Dysfunction in Alzheimer Disease)

Tomas Hromadka tomas.hromadka at gmail.com
Fri Oct 2 17:25:24 CEST 2015

A Marie Sklodowska Curie Actions sponsored European Training Network in
Synaptic Dysfunction in Alzheimer Disease (SyDAD) is seeking 15 PhD


SyDAD is an interdisciplinary PhD programme including an innovative
research programme with cutting edge methodology, an excellent training
programme, international exchanges and a translational and collaborative

1. To foster a new generation of researchers with an innovative mind-set
and full understanding of the requirements of academia, pharmaceutical
companies, the clinics and the societal challenges.
2. To, through a collaborative research programme, elucidate how the
different pathways underlying synaptic dysfunction in Alzheimer Disease
(AD) relate to each other, to identify novel pharmaceutical targets and
to elaborate a drug discovery platform.

The doctoral students will use biochemical, cell biological,
electrophysiological and in vivo methods as well as clinical material.
The network has access to a wide repertoire of cutting-edge methodology
including super-resolution microscopy, mass spectrometry, in vivo
electrophysiology and optogenetics. The doctoral students will be
seconded to other sites of the network during shorter periods to best
utilize the resources of the network and participate in a common
training programme at the different sites of the network.

For more information about the projects, please see the SyDAD web site

Karolinska Institutet, Stockholm, Sweden
ESR 10: Targeting Cholesterol homeostasis and synaptic maturation.
Contact: angel.cedazo-minguez at ki.se
ESR 11: Synaptic proteome and Aβ interactome in AD brain and mouse
models. Contact: susanne.frykman at ki.se
ESR 13: EEG as a functional central biomarker in AD. Contact:
vesna.jelic at ki.se
ESR 14: Mitochondria stabilisers and synaptic function in AD. Contact:
maria.ankarcrona at ki.se
Apply to the projects at Karolinska Institutet at

University of Bordeaux, France
ESR 2: Role of APP in presynaptic mechanisms. Contact:
gael.barthet at u-bordeaux.fr
ESR 7: Mitochondrial dysfunction in relation to synaptic function in
mouse models of Alzheimer’s disease. Contact: Sandrine Pouvreau
sandrine.pouvreau at u-bordeaux.fr
ESR 12: Plasticity of local hippocampal circuits in mouse models of
Alzheimer's disease: relation with episodic memory encoding. Contact:
christophe.mulle at u-bordeaux.fr
Apply to the projects at University of Bordeaux by e-mail:
christophe.mulle at u-bordeaux.fr

University of Milano, Italy
ESR 1: Linking actin-dependent dendritic spine remodelling and ADAM10
activity in AD: the role of CAP2. Contact: monica.diluca at unimi.it
ESR 9: A spine to nucleus signalling pathway in Alzheimer's disease.
Contact: fabrizio.gardoni at unimi.it
ESR 15: Development of cell permeable peptides capable of increasing
ADAM10 activity. Contact: monica.diluca at unimi.it
Apply to the projects at University of Milano by e-mail:
monica.diluca at unimi.it and fabrizio.gardoni at unimi.it

Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
ESR 3: Cascade linking Aß and tau-dependent toxicity to synapse loss.
Contact: Mandelkow at dzne.de
ESR 4: Loss-of-function genetic screening using CRISPR/Cas9. Contact:
Daniele.Bano at dzne.de
ESR 8. Synaptic plasticity and calcium remodelling. Contact:
office-nicotera at dzne.de
Apply to the projects at DZNE by e-mail: application at dzne.de

Janssen Pharmaceuticals, Beerse, Belgium
ESR 6: The roles of physiological and pathophysiological tau in synapse
function and morphology. Contact: jpitaalm at ITS.JNJ.com
Apply for the Janssen position here: http://jobs.jnj.com/s/u3z0MT

Axon Neuroscience, Bratislava, Slovakia
ESR 5: Rescue of truncated Tau-mediated synaptic dysfunction in vivo.
Contact: novak at axon-neuroscience.eu
For further information on the application process at Axon Neuroscience,
please contact novak at axon-neuroscience.eu

The entry requirements for each participating university will apply.

The applicant should be a postgraduate researcher in the first four
years (full-time equivalent) of their research activity, including the
period of research training, who has not been awarded a doctoral degree.

NOTE! Mobility rule: The researcher must not have resided or carried out
his/her main activity (work, studies, etc) in the country of his/her
host organisation for more than 12 months in the 3 years immediately
prior to his/her recruitment.

- The applicants should have a genuine interest and solid education in
Neuroscience at a master level or equivalent.
- The applicants should have excellent practical skills in performing
laboratory work. For specific requirements for the different projects,
please contact the respective supervisor.
- The applicants should have substantial experience in performing
independent research projects, e g a Master thesis project
- The applicants should have good collaborative skills and be open-minded.
- The applicants should show good proficiency in written and spoken
English equivalent to TOEFL or IELTS.

An application must contain the following documents in English:
- A personal letter and curriculum vitae including references
- A list of potential other project(s) within the SyDAD network the
applicant applies for in prioritised order.
- A copy of degree certificates and associated certificates.

October 25th 2015

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