[Comp-neuro] What is the precision of synaptic plasticity?

Terry Sejnowski terry at salk.edu
Thu Mar 12 04:44:13 CET 2015


http://biorxiv.org/content/early/2015/03/11/016329

Hippocampal Spine Head Sizes are Highly Precise

Thomas M Bartol, Cailey Bromer, Justin P Kinney, 
Michael A Chirillo, Jennifer N Bourne, Kristen M Harris, 
Terrence J Sejnowski

The size of an EPSP is highly correlated with the
the spine head volume for excitatory synapses
on pyramidal cells.  Spine heads on a dendrite 
originating from the same axon had the same volume,
regardless of whether they were large or small.
This has implications for the precision of the 
mechanisms underlying synaptic plasticity.

Terry

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