[Comp-neuro] Postodoctoral position in Valparaiso, Chile

Patricio Orio patricio.orio at uv.cl
Wed Nov 20 13:37:10 CET 2013


Funded by CONICYT Grant ACT-1113: Physiological role of TRP channels in
thermotransduction and synaptic plasticity

Research Topic: Mathematical modeling of the electrical activity of cold
sensitive nerve endings.
Post-Doctoral position available at the Computational Neuroscience lab,
Centro Interdisciplinario de Neurociencia de Valparaíso. Dr. Patricio Orio

Mammalian cold sensitive nerve endings generate a variety of rhythmic
firing patterns (tonic or bursting, regular or irregular) that are supposed
to encode skin temperature. These firing patterns are the result of a
collection of ion channels and the different effects that temperature has
on them. A misbalance in the function or expression of these channels leads
to several neuropathies that are not yet easily explained. In order to
understand the dynamics of thermosensation in physiological and
pathological conditions, we will fit and analyze conductance-based models
of cold receptors. We will employ parameter optimization algorithms and
tools for dynamical system analysis. This work will not only shed light
about the role of different ion conductances in cold thermoreceptors, but
also on the robustness of an oscillatory system after dramatic changes of
parameters induced by temperature.

Applicants must be interested in working in an interdisciplinary work
environment, as well as possess mathematical knowledge in dynamical
systems, neural excitability and/or analysis of oscillatory phenomena.
Programming skills are needed and a medium knowledge of Python is

Possible applicant’s profiles include:
PhD in physics or applied mathematics with interest on biological phenomena.
PhD in neuroscience or related areas with advanced mathematical skills.

Applicants please contact Dr. Patricio Orio, patricio.orio at uv.cl or Dr.
Rodolfo Madrid, rodolfo.madrid at usach.cl for more information.

Prof. Patricio Orio
Centro Interdisciplinario de Neurociencias de Valparaíso CINV
Facultad de Ciencias
Universidad de Valparaíso, Chile
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