[Comp-neuro] RE: Post-Doctoral position at Blue Brain Project,
EPFL, in Mesoscale Cortical Synthesis
romain.brette at ens.fr
Tue Jul 9 11:46:58 CEST 2013
Perhaps you might be interested in this little text I wrote about
reductionism on my blog:
Le 06/07/2013 00:16, ramana dodla a écrit :
> I don't know the answers to Jim's questions, but they touch upon
> issues that are
> of importance to (neuro-) scientists. But as a matter of scientific
> quest, and
> from a physics point of view, the idea of a cortical column is
> appealing. I could think of them
> as a set of eigen-shapes that could interact with one another, and
> define the cortical
> communication. For this approach, in fact any other shape would be
> equally good/bad.
> This fits into the idea of methodological reductionism. Physics is a
> nice example.
> The human body itself is another best example. Who knows what is best
> for the brain,
> but I don't know why reductionism shouldn't work in the brain. Isn't
> reductionism the idea
> behind electrophysiology?
> On Thu, Jul 4, 2013 at 9:24 AM, james bower <bower at uthscsa.edu
> <mailto:bower at uthscsa.edu>> wrote:
> Why not, it's the summer, CNS meeting is coming up, and it has
> been a long time since our previous discussion of 'noise in the
> nervous system'.
> So, why not:
> Serious question: do cortical columns actually exist? Is this the
> right way to think about cortical processing?
> More formally, is the idea of a cortical column, originally
> proposed by Mountcastle in the 1950s as a "computational" (in
> current lexicon) building block for cerebral cortex:
> 1) supported by the data
> 2) the right way to think about cortical structure? computational
> or otherwise.
> In case anyone is wondering, I think not - and have found it
> mildly amusing that this project is devoted to reconstructing
> something that probably doesn't exist.
> Jim Bower
> On Jul 4, 2013, at 7:43 AM, Shillcock Julian Charles
> <julian.shillcock at epfl.ch <mailto:julian.shillcock at epfl.ch>> wrote:
>> The Blue Brain Project has modelling infrastructure for
>> constructing in silico neocortical columns containing about
>> 30,000 neurons, distributing the cells through the column and
>> forming synapses. Several such columns have already been
>> assembled into a planar hexagonal mosaic containing up to
>> 1,000,000 neurons. However, axons grow long distances along
>> tracts within the brain's white matter, and the next stage of
>> development is to populate three-dimensional mesh models of brain
>> regions with appropriately-shaped mesocircuits, adjusting their
>> dimensions and shape to match rodent brain anatomy, and
>> connecting the circuits according to known large-scale
>> connectomics data, yielding a complete rat brain model
>> containing on the order of tens of millions of neurons.
>> Please see this page for more deals:
>> Julian Shillcock
>> Comp-neuro mailing list
>> Comp-neuro at neuroinf.org <mailto:Comp-neuro at neuroinf.org>
> Dr. James M. Bower Ph.D.
> Professor of Computational Neurobiology
> Barshop Institute for Longevity and Aging Studies.
> 15355 Lambda Drive
> University of Texas Health Science Center
> San Antonio, Texas 78245
> *Phone: 210 382 0553 <tel:210%20382%200553>*
> Email: bower at uthscsa.edu <mailto:bower at uthscsa.edu>
> Web: http://www.bower-lab.org
> twitter: superid101
> linkedin: Jim Bower
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