[Comp-neuro] RE: Post-Doctoral position at Blue Brain Project, EPFL, in Mesoscale Cortical Synthesis

Romain Brette romain.brette at ens.fr
Tue Jul 9 11:46:58 CEST 2013

Dear Ramana,

Perhaps you might be interested in this little text I wrote about 
reductionism on my blog:


Le 06/07/2013 00:16, ramana dodla a écrit :
> I don't know the answers to Jim's questions, but they touch upon 
> issues that are
> of importance to (neuro-) scientists. But as a matter of scientific 
> quest, and
> from a physics point of view, the idea of a cortical column is 
> appealing. I could think of them
> as a set of eigen-shapes that could interact with one another, and 
> define the cortical
> communication. For this approach, in fact any other shape would be 
> equally good/bad.
> This fits into the idea of methodological reductionism. Physics is a 
> nice example.
> The human body itself is another best example. Who knows what is best 
> for the brain,
> but I don't know why reductionism shouldn't work in the brain. Isn't 
> reductionism the idea
> behind electrophysiology?
> rmn
> On Thu, Jul 4, 2013 at 9:24 AM, james bower <bower at uthscsa.edu 
> <mailto:bower at uthscsa.edu>> wrote:
>     Why not, it's the summer, CNS meeting is coming up, and it has
>     been a long time since our previous discussion of 'noise in the
>     nervous system'.
>     So, why not:
>     Serious question:  do cortical columns actually exist? Is this the
>     right way to think about cortical processing?
>     More formally, is the idea of a cortical column, originally
>     proposed by Mountcastle in the 1950s as a "computational" (in
>     current lexicon)  building block for cerebral cortex:
>     1) supported by the data
>     2) the right way to think about cortical structure?  computational
>     or otherwise.
>     In case anyone is wondering, I think not - and have found it
>     mildly amusing that this project is devoted to reconstructing
>     something that probably doesn't exist.
>     :-)
>     Jim Bower
>     On Jul 4, 2013, at 7:43 AM, Shillcock Julian Charles
>     <julian.shillcock at epfl.ch <mailto:julian.shillcock at epfl.ch>> wrote:
>>     The Blue Brain Project has modelling infrastructure for
>>     constructing in silico neocortical columns containing about
>>     30,000 neurons, distributing the cells through the column and
>>     forming synapses. Several such columns have already been
>>     assembled into a planar hexagonal mosaic containing up to
>>     1,000,000 neurons. However, axons grow long distances along
>>     tracts within the brain's white matter, and the next stage of
>>     development is to populate three-dimensional mesh models of brain
>>     regions with appropriately-shaped mesocircuits, adjusting their
>>     dimensions and shape to match rodent brain anatomy, and
>>     connecting the circuits according to known large-scale
>>     connectomics data,  yielding a complete rat brain model
>>     containing on the order of tens of millions of neurons.
>>     Please see this page for more deals:
>>     http://emploi.epfl.ch/page-94325-en.html
>>     Julian Shillcock
>>     _______________________________________________
>>     Comp-neuro mailing list
>>     Comp-neuro at neuroinf.org <mailto:Comp-neuro at neuroinf.org>
>>     http://www.neuroinf.org/mailman/listinfo/comp-neuro
>     Dr. James M. Bower Ph.D.
>     Professor of Computational Neurobiology
>     Barshop Institute for Longevity and Aging Studies.
>     15355 Lambda Drive
>     University of Texas Health Science Center
>     San Antonio, Texas  78245
>     *Phone: 210 382 0553 <tel:210%20382%200553>*
>     Email: bower at uthscsa.edu <mailto:bower at uthscsa.edu>
>     Web: http://www.bower-lab.org
>     twitter: superid101
>     linkedin: Jim Bower
>     The contents of this email and any attachments to it may be
>     privileged or contain privileged and confidential information.
>     This information is only for the viewing or use of the intended
>     recipient. If you have received this e-mail in error or are not
>     the intended recipient, you are hereby notified that any
>     disclosure, copying, distribution or use of, or the taking of
>     any action in reliance upon, any of the information contained in
>     this e-mail, or
>     any of the attachments to this e-mail, is strictly prohibited and
>     that this e-mail and all of the attachments to this e-mail, if
>     any, must be
>     immediately returned to the sender or destroyed and, in either
>     case, this e-mail and all attachments to this e-mail must be
>     immediately deleted from your computer without making any copies
>     hereof and any and all hard copies made must be destroyed. If you
>     have received this e-mail in error, please notify the sender by
>     e-mail immediately.
>     _______________________________________________
>     Comp-neuro mailing list
>     Comp-neuro at neuroinf.org <mailto:Comp-neuro at neuroinf.org>
>     http://www.neuroinf.org/mailman/listinfo/comp-neuro
> _______________________________________________
> Comp-neuro mailing list
> Comp-neuro at neuroinf.org
> http://www.neuroinf.org/mailman/listinfo/comp-neuro

-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://www.neuroinf.org/pipermail/comp-neuro/attachments/20130709/11b29abb/attachment.html

More information about the Comp-neuro mailing list