[Comp-neuro] Two postdoctoral positions: Molecular and Cellular
Erik De Schutter
erik at oist.jp
Fri Jan 27 08:57:08 CET 2012
Two postdoctoral positions are available in the Computational Neuroscience Unit of Dr. Erik De Schutter at the Okinawa Institute of Science and Technology (http://www.irp.oist.jp/cns/) to model molecular and cellular aspects of cerebellar Purkinje cell function.
The first position is to study the signaling pathways involved in cerebellar long-term depression at the parallel fiber to Purkinje cell synapse. You will be able to use a detailed stochastic model using the STEPS simulator (http://steps.sourceforge.net/) that replicates calcium uncaging experiments in detail (Tanaka et al. Neuron 54, 2007). This well mixed model with about 400 different reactions has generated new insights in the sources of stochasticity in synaptic plasticity. In the future we want to expand this work in two directions: to include diffusion, distributing reactions between the spine and dendrite, and to include induction of parallel fiber long-term potentiation. Candidates should have experience with modeling molecular reactions. Knowledge of cerebellar LTD or of similar systems preferred.
The second position is to use compartmental modeling approaches to study dendritic properties. We are particularly interested in the effects of ion channel modulation on excitability and plasticity; and in modeling growth and development and of the Purkinje cell dendritic forest (http://www.youtube.com/oistedu#p/u/4/hoJxgOdW3-Y). Candidates should have experience in compartmental neuron modeling, preferentially using the NEURON simulator. Knowledge of cerebellar physiology is a plus.
Good English language skills are essential for both projects. There will be ample opportunity to interact with modelers and software developers in the lab who are working on several Purkinje cell and cerebellar related projects and with other scientists at OIST.
We offer attractive financial and working conditions in an English language environment. Initial appointment for two years can start anytime this year. More information about the Okinawa Institute of Science and Technology is available at http://www.oist.jp/
Send curriculum vitae, summary of research interests and experience, and the names of three referees to Dr. Erik De Schutter at erik at oist.jp
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