[Comp-neuro] Towards Mathematical Modeling of Neurological Disease from Cellular Perspectives - May/June 2012 in Toronto, Canada

Frances Skinner frances.skinner at gmail.com
Mon Jan 16 15:03:33 CET 2012

May 14- June 15, 2012
Focus Program on "Towards Mathematical Modeling of Neurological Disease
from Cellular Perspectives"
Hosted by the Fields Institute, Toronto
*Organizing Committee*
Larry Abbott (Columbia Univ.), Sue Ann Campbell (Univ. Waterloo),
Nancy Kopell (Boston Univ.), Frances Skinner (TWRI/UHN and Univ Toronto),
David Terman (Ohio State Univ.)

Organization for Computational Neurosciences (OCNS)

See http://www.fields.utoronto.ca/programs/scientific/11-12/neurodisease/for
more details

Parkinson's Disease Workshop: May 22-23, 2012
Schizophrenia Workshop: May 24-25, 2012
Epilepsy Workshop: May 29-30, 2012
Alzheimer's Disease/Pharmaceuticals Workshop: May 31-June 1, 2012
Anesthesiology/Sleep Disorders Workshop: Jun 4-5, 2012

Additional Travel Awards available for OCNS members

Millions of people suffer from some form of neurological disease, and
abnormalities in brain circuits and their activities are recognized as a
place to focus in untangling brain disorders. Oscillations and dynamic
behaviour produced by neuronal circuits are being examined in the context
of several neurological diseases today. While the functional aspect of the
observed dynamics is not entirely clear, it is clear that cellular aspects
of circuits need to be included in these examinations as specific cell
types have been associated with network dysfunction and neurological
disease. A mechanistic understanding, as can be brought about by
mathematical modeling and analyses, is needed to help advance our
understanding of these complex neurological diseases. However, developing
and analyzing models of normal and pathological dynamic activities in these
complex circuits is highly challenging. This is not only because of the
complexity and detail of the systems themselves, but also because of the
required multi-disciplinary aspect of the work. How does one include
cellular detail in mathematical models to allow linkage to experiment and
neurological disease? What techniques and methods can and should be used to
analyze the models? These difficult questions need to be brought to the
fore to allow us to move forth in our understanding and to provide insights
that would be helpful from diagnostic and drug development perspectives.
In a series of workshops we will bring together neuroscientists,
mathematicians, clinicians and experimentalists to present and consider
these problems from several viewpoints. Speakers in the workshops will
present from clinical, experimental, modeling, and mathematical

Goals for this program include: (i) encouraging trainees in mathematics,
physical sciences, life sciences, and interdisciplinary studies, especially
new researchers and mathematicians, to get involved in this exciting and
challenging field of research, (ii) making neuroscientists more aware of
the mathematical tools available to aid with the study of network models,
(iii) making mathematicians more aware of the challenges involved in
modeling biological networks, and (iv) initiating collaborations.

Frances Skinner, PhD
TWRI/UHN and Univ Toronto
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