[Comp-neuro] Paper on cholinergic modulation of spike generating dynamics.

Boris.Gutkin boris.gutkin at ens.fr
Wed Jan 28 19:48:17 CET 2009

> Dear All
> We are happy to announce our new paper showing how acetylcholine  
> changes the phase response curves of cortical neurons in vitro and  
> possibly switches between the different dynamics classes of spike  
> generation:
> Stiefel KM, Gutkin BS, Sejnowski TJ 2008 Cholinergic Neuromodulation  
> Changes Phase Response Curve Shape and Type in Cortical Pyramidal  
> Neurons. PLoS ONE 3(12): e3947 doi:10.1371/journal.pone.0003947
> http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003947
> Abstract:
> Spike generation in cortical neurons depends on the interplay  
> between diverse intrinsic conductances. The phase response curve  
> (PRC) is a measure of the spike time shift caused by perturbations  
> of the membrane potential as a function of the phase of the spike  
> cycle of a neuron. Near the rheobase, purely positive (type I) phase- 
> response curves are associated with an onset of repetitive firing  
> through a saddle-node bifurcation, whereas biphasic (type II) phase- 
> response curves point towards a transition based on a Hopf-Andronov  
> bifurcation. In recordings from layer 2/3 pyramidal neurons in  
> cortical slices, cholinergic action, consistent with down-regulation  
> of slow voltage-dependent potassium currents such as the M-current,  
> switched the PRC from type II to type I. This is the first report  
> showing that cholinergic neuromodulation may cause a qualitative  
> switch in the PRCs type implying a change in the fundamental  
> dynamical mechanism of spike generation.
> Dr. Boris S Gutkin
> Senior Research Scientist
> Group for Neural Theory
> 29 rue d'Ulm
> 75005 Paris
> tel: +33 (0)1 44 32 26 44
> www.gnt.ens.fr

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