[Comp-neuro] Post-doctoral position at Boston University, Center for Memory and Brain

Michael Hasselmo hasselmo at bu.edu
Wed Feb 25 18:19:12 CET 2009

A full-time postdoctoral position is available in the Center for Memory 
and Brain, Department of Psychology and Program in Neuroscience at Boston 

The post-doctoral fellow will develop compartmental biophysical 
simulations of entorhinal, subicular and hippocampal neurons and circuits 
involved in encoding and retrieval of sequences for memory guided 
behavior.  The post-doctoral fellow will join a large community of 
researchers in the Center for Memory and Brain.

Research will focus initially on developing compartmental biophysical 
simulations of grid cell responses in entorhinal cortex, based on cellular 
mechanisms such as membrane potential oscillations and persistent spiking 
(Giocomo et al., 2007; Hasselmo, 2008a).  Simulations will use standard 
packages such as MATLAB, Neuron and GENESIS.

Modeling will include interaction with experimental work using whole-cell 
patch recording in slice preparations of entorhinal cortex and subiculum 
(Giocomo and Hasselmo, 2008; Yoshida et al., 2008) and experimental work 
on unit recording data in awake, behaving rats (Lee et al., 2006; 
Hasselmo, 2008b).  Collaborations will include Dr. Erik Fransen at the 
Royal Institute of Technology in Stockholm, Sweden, and Prof. Howard 
Eichenbaum and Prof. Chantal Stern in the Center for Memory and Brain at 
Boston University. Simulations will use standard packages such as MATLAB, 
Neuron or GENESIS.

Candidates should have previous experience with developing compartmental 
biophysical simulations of neurons.  E-mail your CV and the e-mail 
addresses of two references to Prof. Michael Hasselmo, hasselmo at bu.edu. 
Boston University is an Affirmative Action, Equal Opportunity Employer.

Citations: (PDF files available at 
Giocomo LM, Zilli EA, Fransen E, Hasselmo ME. (2007) Temporal frequency of 
subthreshold oscillations scales with entorhinal grid cell field spacing. 
Science, 315(5819):1719-22.
Giocomo, L.M., Hasselmo, M.E. (2008) Time constant of I(h) differs along 
dorsal to ventral axis of medial entorhinal cortex. Journal of 
Neuroscience, 28:9414-25.
Hasselmo, M.E. (2008a) Grid cell mechanisms and function: Contributions of 
entorhinal persistent spiking and phase resetting.  Hippocampus 18: 
Hasselmo, M.E. (2008b) Temporally structured replay of neural activity in 
a model of entorhinal cortex, hippocampus and postsubiculum. Eur. J. 
Neurosci. 28:1301-1315.
Lee I., Griffin A., Zilli E., Eichenbaum H., Hasselmo M.E. (2006) Gradual 
translocation of spatial correlates of neuronal firing in the hippocampus 
toward prospective reward locations. Neuron 51:639-50.
Yoshida, M., Fransen, E., Hasselmo, M.E. (2008) mGluR-dependent persistent 
firing in entorhinal cortex layer III neurons. Eur. J. Neurosci. 

Prof. Michael Hasselmo
Center for Memory and Brain
Department of Psychology and
Program in Neuroscience
Boston University,
2 Cummington St.,
Boston, MA, 02215, USA
Tel: (617) 353-1397,
e-mail: hasselmo at bu.edu

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