[Comp-neuro] Query: Calcium Spike

M. Bazhenov bazhenov at salk.edu
Wed Aug 27 17:58:55 CEST 2008

LTS was successfully modeled in Alain Destexhe's (with T.Sejnowski and 
M.Steriade) 199x papers about spindles in thalamus. Later we used the 
same kinetics in some of our studies. E.g.,:

best, Maxim

Harry Erwin wrote:
> Just a query. I'm currently working on a model of an inferior 
> colliculus rebound regular cell. These neurones contain calcium T 
> (Cav3) channels and respond to the end of a period of 
> hyperpolarisation with a 'hump' (a broad multi-msec calcium spike). In 
> bats, sodium spikes can ride on this hump and are believed to indicate 
> that the system has detected an echo after the end of an interval of 
> GABAergic input. Thalamocortical relay and thalamic nucleus 
> reticularis neurones seem to operate in very much the same fashion. 
> Now for the $64,000 question--has anyone managed to model this calcium 
> hump? I'm using the time constants from Huguenard and Prince (1992) 
> and the small calcium spike I'm getting is much too short in duration 
> and in magnitude. The somatic conductances I'm using (in nS/(sq 
> micron)) are Nav1.2, 300; Kv1.4, (4AP-sensitive) 300; Kv1.4, 
> (4AP-resistant) 100; and Cav3, 300. I'm aware that these conductance 
> densities are probably too low, but I would expect the ratios to be 
> more important than the absolute numbers.
> -- 
> Harry Erwin, PhD, Senior Lecturer of Computing, University of 
> Sunderland. Computational neuroethologist:
> http://scat-he-g4.sunderland.ac.uk/~harryerw/phpwiki/index.php/AuditoryResearch 
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Maxim Bazhenov, Ph.D.
Associate Professor
Department of Cell Biology and Neuroscience
University of California
Riverside, CA 92521
Ph: 951-827-4370

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