[Comp-neuro] New Paper

Arjen van Ooyen arjen.van.ooyen at falw.vu.nl
Tue Jul 11 09:11:19 CEST 2006

Generation of Time Delays: Simplified Models of Intracellular Signalling 
in Cerebellar Purkinje Cells

Volker Steuber, David Willshaw & Arjen van Ooyen, Network: Computation 
in Neural Systems (2006) 17: 173-191

In many neuronal systems, information is encoded in temporal spike 
patterns. The recognition and storage of temporal patterns requires the 
generation and modulation of time delays between inputs and outputs. In 
cerebellar Purkinje cells, stimulation of metabotropic glutamate 
receptors (mGluRs) results in a delayed calcium and voltage response 
that has been implicated in classical conditioning and temporal pattern 
recognition. Here, we analyse and simplify a complex model of the 
intracellular signalling network that has been proposed as a substrate 
for this delayed response. We systematically simplify the original 
model, present a minimal model of time delay generation, and show that a 
delayed response can be produced by the combination of negative feedback 
and autocatalysis, without any intervening signalling steps that would 
contribute additive delays. The minimal model is analysed using phase 
plane methods, and classified as an excitable system. We discuss the 
implication of excitability for computations performed by intracellular 
signalling networks in general.

To obtain the full paper in PDF, go to

Dr. Arjen van Ooyen
Department of Experimental Neurophysiology
Center for Neurogenomics and Cognitive Research
Vrije Universiteit Amsterdam
De Boelelaan 1085
1081 HV Amsterdam
The Netherlands

E-mail: arjen.van.ooyen at falw.vu.nl
Phone:  +31.20.5987090
Fax:    +31.20.5987112
Room:   C454
Web:    http://www.bio.vu.nl/enf/vanooyen

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