Models
Spine Tutorial
Demonstrates the new buffered diffusion routines in
GENESIS in the implementation of a simple model
of a dendritic spine.
The mathematical principles are described in:
De Schutter E., and Smolen P.: Calcium dynamics
in large neuronal models. in Methods in neuronal modeling: from ions to networks (2nd
edition), C. Koch and I. Segev editors, 211-250 (1998).
The model is described in: De Schutter E., and Bower
J.M.: Sensitivity of synaptic plasticity to the Ca2+-permeability of NMDA-channels:
a model of long term potentiation in hippocampal neurons. Neural Computation 5: 681-694
(1993).
Click on the image to enlarge
System requirements
To run this tutorial correctly you need to install GENESIS2.2 first.
Simulation scripts
Download the GENESIS scripts for this model
The tar file creates a SpineDemo directory which contains scripts to run the following simulations:
- SPINEDEMO-one.g: simulates a single activation of a NMDA and an AMPA channel on a spine.
- SPINEDEMO-burst.g: simulates a 200Hz burst activation of a NMDA and an AMPA channel on a spine.