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Calcium Dynamics in a Purkinje Cell Model

Welcome to the webpage describing our new Purkinje cell model with detailed calcium dynamics, as described in our upcoming chapter "Calcium dynamics in large neuronal models" (to appear in Methods in neuronal modeling: from synapses to networks, 2nd edition, C. Koch and I. Segev editors).

This page is still under construction and running the Purkinje cell model requires GENESIS 2.1.

You can play a short MPEG movie showing the membrane potential in the Purkinje cell model during several somatic spikes and a single dendritic spike.

We suggest having a look at a longer MPEG movie (640x480, 31.9 MB) showing also the submembrane calcium concentration. Note: for faster playback, but sacrificing resolution, the same movie is available with a faster frame rate but smaller image (320x240, 30.4MB)

Coming soon: the Purkinje cell GENESIS tutorial.

Please return soon and in the mean time enjoy this color image of our Purkinje cell model:

Purkinje cell model

(Click on the image to enlarge)

Membrane potential (A-B) and [Ca2+] in the submembrane shell (C-D) during a dendritic Ca2+ spike in the Purkinje cell model. Figures B and D were taken 5 msec later than A and C. In this example the dendritic spike initiated in the upper right dendrite, but this was not always the case in the model. Note that the increase in [Ca2+] was delayed compared to the depolarization. The lower [Ca2+] in the thick branches (the smooth dendrite) compared to the thinner branches (the spiny dendrite) was caused by the surface-to-volume ratio effect as the Ca2+ channel density was identical in all dendritic compartments.

For other models of the cerebellum and its neurons go to models.